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Deadlock, a novel protein of Drosophila, is required for germline maintenance, fusome morphogenesis and axial patterning in oogenesis and associates with centrosomes in the early embryo

机译：死锁是果蝇的一种新蛋白，是维持胚系，卵小体形态发生和卵子发生中的轴向模式所必需的，并且与早期胚胎的中心体有关

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The deadlock gene is required for a number of key developmental events in Drosophila oogenesis. Females homozygous for mutations in the deadlock gene lay few eggs and those exhibit severe patterning defects along both the anterior–posterior and dorsal–ventral axis. In this study, we analyzed eggs and ovaries from deadlock mutants and determined that deadlock is required for germline maintenance, stability of mitotic spindles, localization of patterning determinants, oocyte growth and fusome biogenesis in males and females. Deadlock encodes a novel protein which colocalizes with the oocyte nucleus at midstages of oogenesis and with the centrosomes of early embryos. Our genetic and immunohistological experiments point to a role for Deadlock in microtubule function during oogenesis.

机译：死锁基因是果蝇卵子发生中许多关键发育事件所必需的。死锁基因突变纯合子的雌性产卵很少，而那些在前后轴和后腹轴上均表现出严重的模式缺陷。在这项研究中，我们分析了死锁突变体的卵和卵巢，并确定死锁是种系维持，有丝分裂纺锤体稳定性，模式决定簇的定位，卵母细胞生长和雄性和雌性生物发生所必需的。死锁编码一种新型蛋白质，该蛋白质在卵子发生的中期与卵母细胞核共定位，并与早期胚胎的中心体共定位。我们的遗传和免疫组织学实验指出死锁在卵子发生过程中在微管功能中的作用。

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Wehr, Kristina; Swan, Andrew; Schüpbach, Trudi;
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年度 2006
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1. Deadlock, a novel protein of Drosophila, is required for germline maintenance, fusome morphogenesis and axial patterning in oogenesis and associates with centrosomes in the early embryo [J] . Wehr K, Swan A, Schupbach T Developmental biology . 2006,第2期

机译：死锁是果蝇的一种新型蛋白质，是维持胚系，卵形形态发生和卵子发生中的轴向模式所必需的，并且与早期胚胎中的中心体有关
2. Deadlock, a novel protein of Drosophila, is required for germline maintenance, fusome morphogenesis and axial patterning in oogenesis and associates with centrosomes in the early embryo [J] . Wehr Kristina, Swan Andrew, Schupbach Trudi Developmental biology . 2006,第2期

机译：死锁是果蝇的一种新型蛋白质，是维持胚系，卵形形态发生和卵子发生中的轴向模式所必需的，并且与早期胚胎中的中心体有关
3. Deadlock, a novel protein of Drosophila, is required for germline maintenance, fusome morphogenesis and axial patterning in oogenesis and associates with centrosomes in the early embryo [J] . Kristina Wehr, Andrew Swan, Trudi Schuuml, Developmental biology . 2006,第2期

机译：死锁是果蝇的一种新蛋白，是维持胚系，卵小体形态发生和卵子发生中的轴向模式所必需的，并且与早期胚胎中的中心体有关
4. Patterning and morphogenesis during Drosophila oogenesis. [D] . Zartman, Jeremiah James. 2009

机译：果蝇卵子发生过程中的模式和形态发生。
5. The posterior determinant gene nanos is required for the maintenance of the adult germline stem cells during Drosophila oogenesis. [O] . K M Bhat 1999

机译：在果蝇卵子发生期间维持成年种系干细胞需要后决定簇基因nanos。
6. Deadlock, a novel protein of Drosophila, is required for germline maintenance, fusome morphogenesis and axial patterning in oogenesis and associates with centrosomes in the early embryo [O] . Wehr Kristina, Swan Andrew, Schüpbach Trudi 2006

机译：死锁是果蝇的一种新蛋白，是维持胚系，卵小体形态发生和卵子发生中的轴向模式所必需的，并且与早期胚胎的中心体有关

Deadlock, a novel protein of Drosophila, is required for germline maintenance, fusome morphogenesis and axial patterning in oogenesis and associates with centrosomes in the early embryo

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